Chapter 10
Calculus for Biology and Medicine ยท 290 exercises
Problem 28
Given a function \(f(x, y)\) that is defined and differentiable on an open ball containing the point \(\left(x_{0}, y_{0}\right)\), show that the function \(f\) decreases most rapidly in the direction of \(-\nabla f\left(x_{0}, y_{0}\right)\).
5 step solution
Problem 28
Show that the equilibrium \(\left[\begin{array}{l}0 \\ 0\end{array}\right]\) of $$ \begin{array}{l} x_{1}(t+1)=\frac{3 x_{2}(t)}{2\left(1+\left(x_{1}(t)\right)^{2}\right)} \\ x_{2}(t+1)=\frac{2 x_{1}(t)}{1+\left(x_{2}(t)\right)^{2}} \end{array} $$ is unstable.
6 step solution
Problem 29
(a) Write $$h(x, y)=e^{x y}$$ as a composition of two functions. (b) For which values of \((x, y)\) is \(h(x, y)\) continuous?
2 step solution
Problem 29
Find the Jacobi matrix for each given function. \(\mathbf{f}(x, y)=\left[\begin{array}{c}x+y \\ x^{2}-y^{2}\end{array}\right]\)
4 step solution
Problem 29
Find the maximum volume of a rectangular closed (top, bottom, and four sides) box with surface area \(48 \mathrm{~m}^{2}\).
8 step solution
Problem 29
Suppose an organism moves down a sloped surface along the steepest line of descent, i.e., the direction in which the surface decreases most rapidly. If the surface is given by $$ f(x, y)=x^{2}-y^{2} $$ find the direction in which the organism will move at the point \((2,3)\)
4 step solution
Problem 30
The oxygen content of blood depends on the partial pressure of oxygen in surrounding tissues \((P)\) and on a reaction rate constant \((K) .\) Blood oxygenation is often modcled using Hill's equation, which predicts that the fraction of hemoglobin molecules in blood that are bound to oxygen will be given by a function of \(P\) and \(K\) : $$f(P, K)=\frac{P^{3}}{K^{3}+P^{3}}$$ (a) Explain why, if \(K>0\) and \(P \geq 0, f(P, K)<1\) and \(f(P, K) \geq 0\) (b) Use partial differentiation to determine the effect of increasing \(P\) on \(f\). (c) Use partial differentiation to determine the effect of increasing \(K\) on \(f\).
3 step solution
Problem 30
(a) Write $$h(x, y)=\cos (y-x)$$ as a composition of two functions. (b) For which values of \((x, y)\) is \(h(x, y)\) continuous?
5 step solution
Problem 30
Find the Jacobi matrix for each given function. \(\mathbf{f}(x, y)=\left[\begin{array}{c}2 x-3 y \\ 4 x^{2}\end{array}\right]\)
4 step solution
Problem 30
Find the maximum volume of a rectangular open (bottom and four sides, no top) box with surface area \(75 \mathrm{~m}^{2}\).
6 step solution
Problem 30
Show that, for any \(a>1\), the equilibrium \(\left[\begin{array}{l}0 \\\ 0\end{array}\right]\) of $$ \begin{array}{l} x_{1}(t+1)=x_{2}(t) \\ x_{2}(t+1)=\frac{a x_{2}(t)-(a-1) x_{1}(t)}{a+x_{1}(t)} \end{array} $$ is locally stable.
7 step solution
Problem 31
Find \(\partial f / 2 x, \partial f / \partial y\), and \(\partial f / \partial z\) for the given functions. \(f(x, y, z)=x^{2} z+y z^{2}-x y\)
3 step solution
Problem 31
Draw an open disk with radius 2 centered at \((1,-1)\) in the \(x-y\) plane, and give a mathematical description of this set.
4 step solution
Problem 31
Use nine evenly spaced points and five colors to draw heat maps of the following functions, defined on their specified domains. \(f(x, y)=x^{2}+y^{2}\) on \(D=\\{(x, y) ; 0 \leq x \leq 1,0 \leq y \leq 1\\}\)
5 step solution
Problem 31
Find the Jacobi matrix for each given function. \(\mathbf{f}(x, y)=\left[\begin{array}{c}e^{x-y} \\ e^{x+y}\end{array}\right]\)
5 step solution
Problem 31
Find the minimum surface area of a rectangular closed (top, bottom, and four sides) box with volume \(64 \mathrm{~m}^{3}\).
7 step solution
Problem 31
Show that \(\left[\begin{array}{l}0 \\ 0\end{array}\right]\) is an equilibrium point of $$ \begin{array}{l} x_{1}(t+1)=a x_{2}(t) \\ x_{2}(t+1)=x_{1}(t)-\cos \left(x_{2}(t)\right)+1 \end{array} $$ Assume that \(a>0\). For which values of \(a\) is \(\left.\right|_{0} ^{0}\) locally stable?
7 step solution
Problem 32
Find \(\partial f / 2 x, \partial f / \partial y\), and \(\partial f / \partial z\) for the given functions. \(f(x, y, z)=x y(z+x)\)
4 step solution
Problem 32
Draw a closed disk with radius 3 centered at \((2,0)\) in the \(x-y\) plane, and give a mathematical description of this set.
4 step solution
Problem 32
Use nine evenly spaced points and five colors to draw heat maps of the following functions, defined on their specified domains. \(f(x, y)=x-y\) on \(D=\\{(x, y): 0 \leq x \leq 1,0 \leq y \leq 1\\}\)
6 step solution
Problem 32
Find the Jacobi matrix for each given function. \(\mathbf{f}(x, y)=\left[\begin{array}{c}(x-y)^{2} \\ \sin (x-y)\end{array}\right]\)
4 step solution
Problem 32
Find the minimum surface area of a rectangular open (bottom and four sides, no top) box with volume \(256 \mathrm{~m}^{3}\).
8 step solution
Problem 32
Show that \(\left[\begin{array}{l}0 \\ 0\end{array}\right]\) and \(\left[\begin{array}{l}\pi \\ \pi\end{array}\right]\) are equilibria of $$ \begin{array}{l} x_{1}(t+1)=x_{2}(t) \\ x_{2}(t+1)=\sin \left(x_{2}(t)\right)+x_{1}(t) \end{array} $$ and analyze their stability.
4 step solution
Problem 33
Give a geometric interpretation of the set $$A=\left\\{(x, y) \in \mathbf{R}^{2}: \sqrt{x^{2}+y^{2}-4 y+4}<3\right\\}$$
5 step solution
Problem 33
Use nine evenly spaced points and five colors to draw heat maps of the following functions, defined on their specified domains. \(f(x, y)=x^{2}-y^{2}\) on \(D=\\{(x, y):-1 \leq x \leq 1,-1 \leq y \leq 1\\}\)
5 step solution
Problem 33
Find the Jacobi matrix for each given function. \(\mathbf{f}(x, y)=\left[\begin{array}{l}\cos (x-y) \\ \cos (x+y)\end{array}\right]\)
4 step solution
Problem 33
The distance between the origin \((0,0,0)\) and the point \((x, y, z)\) is $$\sqrt{x^{2}+y^{2}+z^{2}}$$ Find the minimum distance between the origin and the plane \(x+y+z=1\). (Hint: Minimize the squared distance between the origin and the plane.)
6 step solution
Problem 33
Find all nonnegative equilibria of $$ \begin{array}{l} x_{1}(t+1)=x_{2}(t) \\ x_{2}(t+1)=\frac{x_{1}(t)}{4}-\frac{x_{2}(t)}{4}+\left(x_{2}(t)\right)^{2} \end{array} $$ and analyze their stability.
6 step solution
Problem 34
Give a geometric interpretation of the set $$A=\left\\{(x, y) \in \mathbf{R}^{2}: \sqrt{x^{2}+6 x+y^{2}-2 y+10}<2\right\\}$$
6 step solution
Problem 34
Find the Jacobi matrix for each given function. \(\mathbf{f}(x, y)=\left[\begin{array}{c}\ln (x+y) \\\ e^{x+y}\end{array}\right]\)
4 step solution
Problem 34
Given the symmetric matrix $$A=\left[\begin{array}{ll} a & c \\ c & b \end{array}\right]$$ where \(a, b\), and \(c\) are real numbers, show that the eigenvalues of \(A\) are real.
6 step solution
Problem 35
Find \(\partial f / 2 x, \partial f / \partial y\), and \(\partial f / \partial z\) for the given functions. \(f(x, y, z)=e^{x+y+z}\)
4 step solution
Problem 35
Let $$f(x, y)=2 x^{2}+y^{2}$$. Use the \(\epsilon-\delta\) definition of limits to show that $$\lim _{(x, y) \rightarrow(0,0)} f(x, y)=0$$
5 step solution
Problem 35
At the beginning of this chapter we introduced the heat index as a way of calculating how temperature and humidity affect the apparent temperature. The equation for the heat index is: \(\begin{aligned} H(T, R)=&-42.38+2.049 T+10.14 R-6.838 \times 10^{-3} T^{2} \\\ &-0.2248 T R-5.482 \times 10^{-2} R^{2}+1.229 \times 10^{-3} T^{2} R \\\ &+8.528 \times 10^{-4} T R^{2}-1.99 \times 10^{-6} T^{2} R^{2} \end{aligned}\) where \(T\) is the actual air temperature (in \({ }^{\circ} \mathrm{F}\) ) and \(R\) is the relative humidity (in \%). Using nine evenly spaced points and five colors, make a heat map for the heat index for the domain \(D=\\{(T, R):\) \(80 \leq T \leq 100,40 \leq R \leq 60]\). (You will find it easiest to calculate the heat index, \(H\), if you program the formula for the heat index into a graphing calculator.)
5 step solution
Problem 35
Find the Jacobi matrix for each given function. \(\mathbf{f}(x, y)=\left[\begin{array}{c}2 x^{2} y-3 y+x \\ e^{x} \sin y\end{array}\right]\)
5 step solution
Problem 35
Species Diversity A frequently used measure of the diversity of an habitat is the Shannon index: $$H=-\sum_{i=1}^{n} p_{i} \ln p_{i}$$ where \(p_{i}\) is equal to the proportion organisms in the area that are species \(i, i=1,2, \ldots, n\), and \(n\) is the total number of species in the study area. Assume that a habitat harbors three species with relative proportions \(p_{1}, p_{2}\), and \(p_{3}\). (a) Use the fact that \(p_{1}+p_{2}+p_{3}=1\) to show that \(H\) is of the form $$\begin{aligned} H\left(p_{1}, p_{2}\right)=&-p_{1} \ln p_{1}-p_{2} \ln p_{2} \\ &-\left(1-p_{1}-p_{2}\right) \ln \left(1-p_{1}-p_{2}\right) \end{aligned}$$ and that the domain of \(H\left(p_{1}, p_{2}\right)\) is the triangular set in the \(p_{1}-p_{2}\) plane bounded by the lines \(p_{1}=0, p_{2}=0\), and \(p_{1}+p_{2}=1\). (b) Show that \(H\) attains its global maximum when \(p_{1}=p_{2}=\) \(p_{3}=1 / 3 .\) (Hint : You may assume \(0 \ln 0=0\) ).
4 step solution
Problem 35
For which values of \(a\) is the equilibrium \(\left[\begin{array}{l}0 \\\ 0\end{array}\right]\) of $$ \begin{array}{l} x_{1}(t+1)=\frac{a x_{2}(t)}{1+\left(x_{1}(t)\right)^{2}} \\ x_{2}(t+1)=\frac{2 x_{1}(t)}{1+\left(x_{2}(t)\right)^{2}} \end{array} $$ locally stable?
5 step solution
Problem 36
Find \(\partial f / 2 x, \partial f / \partial y\), and \(\partial f / \partial z\) for the given functions. . \(f(x, y, z)=\sin (x+y-z)\)
4 step solution
Problem 36
Let $$f(x, y)=2 x^{2}+3 y^{2}$$ Use the \(\epsilon-\delta\) definition of limits to show that $$\lim _{(x, y) \rightarrow(0,0)} f(x, y)=0$$
6 step solution
Problem 36
Find the Jacobi matrix for each given function. \(\mathbf{f}(x, y)=\left[\begin{array}{c}\sqrt{x^{2}+y^{2}} \\\ e^{-x^{2}}\end{array}\right]\)
5 step solution
Problem 36
Use Lagrange multipliers to find the maxima and minima of the functions under the given constraints. $$ f(x, y)=2 x-y ; x^{2}+y^{2}=5 $$
7 step solution
Problem 36
For which values of \(a\) is the equilibrium \(\left[\begin{array}{l}0 \\\ 0\end{array}\right]\) of $$ \begin{array}{l} x_{1}(t+1)=x_{2}(t) \\ x_{2}(t+1)=\frac{-1}{2} x_{1}(t)+a x_{2}(t)-\left(x_{2}(t)\right)^{2} \end{array} $$ locally stable?
7 step solution
Problem 37
Use Lagrange multipliers to find the maxima and minima of the functions under the given constraints. $$ f(x, y)=4 x^{2}+y ; x^{2}+y^{2}=1 $$
6 step solution
Problem 37
Denote by \(x_{1}(t)\) the number of juveniles, and by \(x_{2}(t)\) the number of adults, at time \(t\). Assume that \(x_{1}(t)\) and \(x_{2}(t)\) evolve according to $$ \begin{array}{l} x_{1}(t+1)=x_{2}(t) \\ x_{2}(t+1)=\frac{1}{2} x_{1}(t)+r x_{2}(t)-\left(x_{2}(t)\right)^{2} \end{array} $$ (a) Show that if \(r>1 / 2\), there exists an equilibrium \(\left[\begin{array}{c}x_{1}^{*} \\ x_{2}^{*}\end{array}\right]\) with \(x_{1}^{*}>0\) and \(x_{2}^{*}>0 .\) Find \(x_{1}^{*}\) and \(x_{2}^{*}\). (b) Determine the stability of the equilibrium found in (a) when \(r>1 / 2\)
7 step solution
Problem 38
Find a linear approximation to each func\mathrm{tion } \(f(x, y)\) at the indicated point. \(\mathbf{f}(x, y)=\left[\begin{array}{c}3 x-y^{2} \\ 4 y\end{array}\right]\) at \((-1,-2)\)
5 step solution
Problem 38
Use Lagrange multipliers to find the maxima and minima of the functions under the given constraints. $$f(x, y)=x y ; x+y=4$$
7 step solution
Problem 39
Find the indicated partial derivatives. \(f(x, y)=x^{2} y^{2}+2 x y^{2} ; \frac{a^{2} f}{\partial x^{2}}\)
3 step solution
Problem 39
Determine the equation of the level curves \(f(x, y)=c\) and sketch the level curves for the specified values of \(c\). \(f(x, y)=x+y ; c=0,-1,1\)
6 step solution
Problem 39
Use Lagrange multipliers to find the maxima and minima of the functions under the given constraints. $$ f(x, y)=x y ; x^{2}+4 y^{2}=1 $$
8 step solution
Problem 39
Host-Parasitoid Interactions Find all biologically relevant equilibria of the Nicholson-Bailey model $$ \begin{array}{l} N_{t+1}=4 N_{t} e^{-0.1 P_{i}} \\ P_{t+1}=N_{t}\left[1-e^{-0.1 P_{t}}\right] \end{array} $$ and analyze their stability.
6 step solution