Q45. - Organic Chemistry

Question

Question: Devise a synthesis of valproic acid [(CH₃CH₂CH₂)₂ CHC0₂H], a medicine used to treat epileptic seizures, using the malonic ester synthesis.

Step-by-Step Solution

Answer

Answer

 

The malonic ester reaction for the synthesis of valproic acid is shown below.

Step 1: Retrosynthetic pathway for obtaining the starting materials

To obtain the starting materials required for acetoacetic ester synthesis, a retrosynthetic analysis is followed. It is as shown below:

Step 2: Forward pathway for obtaining the product

To obtain the product, a forward reaction scheme analysis is followed, as shown below.

Representation of the forward pathway to obtain the product