Q38E
Question
The Knoevenagel reaction is a carbonyl condensation reaction of an ester with an aldehyde or ketone to yield an α,β-unsaturated product. Show the mechanism for the Knoevenagel reaction of diethyl malonate with benzaldehyde.
Step-by-Step Solution
Verified Answer
Benzaldehyde reacts with diethyl malonate to produce cinnamic acid.
1Reaction
The Knoevenagal reaction is a carbonyl condensation reaction of an ester with an aldehyde or ketone to yield α,β-unsaturated product.
The given reaction is,
2Mechanism
The mechanism for the above process is as follows,
Other exercises in this chapter
Q36E
The first step in the citric acid cycle of food metabolism is reaction of oxaloacetate with acetyl CoA to give citrate. Propose a mechanism, using acid or base
View solution Q37E
The amino acid leucine is biosynthesized from α-ketoisovalerate by the following sequence of steps. Show the mechanism of each.
View solution Q39E
The Darzens reaction involves a two-step, base-catalyzed condensation of ethyl chloroacetate with a ketone to yield an epoxy ester. The first step is a carbonyl
View solution Q40E
The following reaction involves a hydrolysis followed by an intramolecular nucleophilic acyl substitution reaction. Write both steps, and show their mechanisms.
View solution