Q28-18E - Organic Chemistry (Mcmurry)

Question

One of the steps in the biosynthesis of a nucleotide called inosine monophosphate is the formation of aminoimidazole ribonucleotide from formyglycinamidine ribonucleotide. Propose a mechanism.

Step-by-Step Solution

Answer

The mechanism for the biosynthesis of a nucleotide called inosine monophosphate is

Definition of mechanism

The sequence of elementary steps by which a chemical reaction occurs is defined as a mechanism.

Explanations

Formyglycinamidine ribonucleotide is converted to aminoimidazole ribonucleotide by the reaction with ATP and ammonia. FGAM catalyses the reaction. The process is very similar to what occurs in the conversion of uridine triphosphate to cytidine triphosphate.

Formyglycinamidine ribonucleotide is converted to aminoimidazole ribonucleotide by reacting with ATP and removing the ADP and phosphate group.

The mechanism for the biosynthesis of a nucleotide called inosine monophosphate is