Q. 18.29 - An Introduction to General, Organic, and Biological Chemistry

Question

What condition is needed in the cell to convert pyruvate to $\mathrm{acetyl} \mathrm{CoA}$?

Step-by-Step Solution

Answer

The anaerobic environment is needed in the cell to convert pyruvate to $\mathrm{acetyl} \mathrm{CoA}$

Step 1: Given information

We need to find the condition in the cell to convert pyruvate to $\mathrm{acetyl} \mathrm{CoA}$

Step 2: Explanation

The conversion of pyruvate to $\mathrm{acetyl} \mathrm{CoA}$ requires an aerobic environment. The enzyme oxidizes pyruvate, releasing the carboxyl group from pyruvate and creating carbon dioxide as a result. ${\mathrm{NAD}}^{+}$ is decreased during the reaction step as the pyruvate is oxidized. The $\mathrm{CoA}$ then bonds to the two-carbon acetyl molecule to form $\mathrm{acetyl} \mathrm{CoA}$.