Chapter 20

The specific feedback effector for FSH is a. Inhibin b. Activin c. Progesterone d. Estradiol

Which anterior pituitary hormone lacks a stimulatory hypophysiotropic hormone? a. Prolactin b. Growth hormone c. Vasopressin d. ACTH

Which of the following is influenced by growth hormone? a. All of these b. IGF-I c. IGFBP-III d. Lipolysis

What are the long-term sequelae of untreated or partially treated acromegaly? a. An increased risk of colon and lung cancer b. A reduced risk of heart disease c. Enhanced longevity d. Increased muscle strength

TRH stimulates the secretion of a. Prolactin and TSH b. Prolactin c. Growth hormone d. TSH

Estrogen influences the secretion of which of the following hormones? a. All of these b. Growth hormone c. Prolactin d. Luteinizing hormone

What is the difference between a tropic hormone and a direct effector hormone? a. Tropic and direct effector hormones are both similar in that both act directly on peripheral tissue. b. Tropic and direct effector hormones are both similar in that both act directly on another endocrine gland. c. Tropic hormones act on peripheral tissue, while direct effector hormones act on endocrine glands. d. Tropic hormones act on endocrine glands, while direct effector hormones act on peripheral tissues.

A deficiency in vasopressin can lead to which of the following? a. Euvolemic hypokalemia b. Euvolemic hyponatremia c. Diabetes insipidus d. Primary hypothyroidism

Which hormone most directly stimulates testosterone secretion? a. LH b. FSH c. GnRH d. TRH

Which of the following is NOT likely to be present in an “atypical pituitary tumor” as defined by the World Health Organization (WHO)? a. Invasion into surrounding structures such as the cavernous sinus b. MIB-1 proliferative index greater than 3% c. Excessive p53 immunoreactivity d. Decreased mitotic activity

Concerning secretion of growth hormone, which of the following is NOT true? a. Secretion is stimulated by GHRH. b. Secretion is pulsatile, occurring usually 2 to 3 times daily. c. The most reproducible surge is at the onset of sleep. d. It is secreted from somatotrophs that constitute over one-third of normal pituitary weight

Cosecretion of which hormone is most commonly seen with acromegaly? a. Prolactin b. TSH c. ACTH d. FSH

Which hormone is not secreted from the anterior pituitary? a. Prolactin b. Oxytocin c. FSH d. TSH

Which of the following is most suggestive of a diagnosis of diabetes insipidus? a. Low sodium in a patient who reports polydipsia and polyuria b. Persistent complaint of polydipsia and polyuria in a patient without diabetes mellitus c. Elevated serum osmolarity in the setting of decreased urine osmolarity, in the presence of hypernatremia d. Hyponatremia after a therapeutic trial of dDAVP

Vasopressin release is regulated by which of the following? a. Hypothalamic osmoreceptors b. Vascular baroreceptors c. V2 receptors in the kidney d. a and b

Replacement of thyroxine is potentially dangerous in the setting of which other hormonal abnormality? a. GH deficiency b. Hyperprolactinemia c. Perimenopausal state d. ACTH deficiency

Which of the following is NOT generally considered to be a function of oxytocin? a. Uterine contraction during labor b. Milk "letdown" for breast-feeding c. Enhancement of insulin sensitivity in smooth muscle d. Enhancement of mother-infant bonding

Which clinical presentation is consistent with Kallmann's syndrome? a. Hypothyroidism and intermittent severe weakness or paralysis b. ACTH deficiency together with GH excess c. Hyperprolactinemia in the setting of pregnancy d. Hypogonadism with the absence of smell

Which drug may cause panhypopituitarism? a. Ipilimumab b. Risperdal c. Pitocin d. Cabergoline

Which of the following is unlikely to be a cause of hyperprolactinemia? a. Metoclopramide b. Primary hypothyroidism c. Primary hypogonadism d. Pituitary stalk interruption