Chapter 35

A patient takes nateglinide before each meal. Which mechanism is responsible for the therapeutic effect of this drug? (A) closing of potassium channels (B) slowed gastric emptying (C) inhibition of \(\alpha\)-glucosidase (D) inhibition of DPP-4 (E) insertion of glucose transporters in cell membranes

A patient with type 1 diabetes injects pramlintide at mealtimes. Which adverse effect may result from this drug? (A) increased appetite (B) nausea and anorexia (C) flatulence and bloating (D) weight gain (E) increased risk of heart failure

A diabetic patient takes pioglitazone. Which effect is produced by this drug? (A) increased insulin secretion (B) lowered high-density lipoprotein cholesterol levels (C) increased serum triglyceride levels (D) insertion of glucose transporters in cell membranes (E) weight loss

Which of the following phrases correctly describes insulin glargine? (A) it is injected at mealtimes (B) proline and lysine are transposed in the B chain (C) aspartate is substituted for proline in the B chain (D) it is slowly absorbed over 24 hours (E) it is administered by inhalation

A type 2 diabetic patient is prescribed metformin. Which adverse effect often occurs when taking this drug? (A) heart failure (B) weight gain (C) diarrhea (D) lactic acidosis (E) hypoglycemia