Chapter 13

Which of the following types of molecules could bind to an ncRNA through base pairing? a. DNA b. RNA c. protein d. small molecule e. both a and b

Which of the following is not a general function of an ncRNA? a. encoding a polypeptide b. acting as a ribozyme c. acting as a guide d. acting as a scaffold e. acting as a decoy

ncRNAs play an important role in a. DNA replication. b. chromatin structure and transcription. c. translation and RNA degradation. d. genome defense. e. all of the above.

HOTAIR causes certain genes to be repressed by facilitating a. the binding of a repressor protein. b. the release of an activator protein. c. the covalent modification of histones. d. the removal of nucleosomes. e. both a and c.

One of the roles of the RNA component of signal recognition particle (SRP) is to stimulate certain proteins to hydrolyze GTP. If this function of SRP RNA did not work properly, what would you expect to happen? a. SRP would not bind to the ER signal sequence of a polypeptide. b. SRP would not cause translation to pause. c. SRP would not bind to an SRP receptor in the ER membrane. d. SRP would not be released from the ER membrane. e. both a and b

During RNA interference, what binds to an mRNA to inhibit translation? a. a pri-miRNA b. a pre-miRNA or pre-siRNA c. a double-stranded miRNA or double-stranded siRNA d. a single-stranded miRNA or single-stranded siRNA e. dicer

With regard to miRNAs and siRNAs, which of the following statements is (are) correct? a. miRNAs are transcribed from endogenous genes. b. miRNAs are usually a perfect match to an mRNA. c. siRNAs are transcribed from endogenous genes. d. siRNAs cause mRNA degradation. e. both a and d

Cas 1 and Cas2 proteins play a role during which of the following phases of genome defense? a. adaptation b. expression c. interference d. both adaptation and expression e. both expression and interference

Which of the following components bind to tracrRNA? a. crRNA and Casl protein b. crRNA and Cas2 protein c. crRNA and Cas9 protein d. crRNA only e. Casl and Cas2 proteins

Abnormalities in the expression of ncRNAs are associated with a. many forms of cancer. b. neurological disorders. c. cardiovascular diseases. d. all of the above. e. only a and b.