Chapter 25
An Introduction to Medicinal Chemistry · 3 exercises
Problem 1
Omeprazole is administered orally as a galenic formulation to protect it from being activated during its journey through the acidic contents of the stomach. Once it is released in the intestines, it is absorbed into the blood supply and carried to the parietal cells where it crosses the cell membrane into the canaliculi and is activated. As the canaliculi lead directly into the lumen of the stomach, why is omeprazole not orally administered directly to the stomach?
4 step solution
Problem 5
The phenol (III) is a very difficult compound to synthesize and is unstable at
neutral \(\mathrm{pH}\). Suggest why this might be the case.
5 step solution
Problem 8
The acidic contents of the stomach encourage the digestion of food and the destruction of cells. Why are the cells lining the stomach not digested in that case?
4 step solution