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TextbooksChemistryAn Introduction to Medicinal ChemistryChapter 18

Chapter 18

An Introduction to Medicinal Chemistry · 1 exercises

Problem 3

A lead compound has a monosubstituted aromatic ring present as part of its structure. An analogue was synthesized containing a para-chloro substituent which had approximately the same activity. It was decided to synthesize an analogue bearing a methyl group at the paraposition. This showed increased activity. What analogue would you prepare next and why?

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