Chapter 3

What was Loewi's evidence that neurotransmission depends on the release of chemicals?

Is a drug with high affinity and low efficacy an agonist or an antagonist?

Name the three catecholamine neurotransmitters.

What is the difference between temporal summation and spatial summation?

What does a highly active brain area do to increase its blood supply?

When the action potential reaches the presynaptic terminal, which ion must enter the presynaptic terminal to evoke release of the neurotransmitter?

How do ionotropic and metabotropic synapses differ in speed and duration of effects?

What are second messengers, and which type of synapse relies on them?

Which has longer lasting effects, a neurotransmitter or a hormone? Which affects more organs?

Which part of the pituitary-anterior or posterior-is neural tissue, similar to the hypothalamus? Which part is glandular tissue and produces hormones that control the secretions by other endocrine organs?

If incoming serotonin axons were destroyed, LSD would still have its normal effects on the postsynaptic cell. However, if incoming dopamine and norepinephrine axons were destroyed, amphetamine and cocaine would have no effects. Explain the difference.

What happens to serotonin and catecholamine molecules after they stimulate a postsynaptic receptor?