Chapter 21
An Introduction to Medicinal Chemistry · 2 exercises
Problem 3
As esters are commonly used as prodrugs, esterases would be suitable enzymes to use in ADEPT. What are your thoughts on this statement?
4 step solution
Problem 5
CGP 52411 is a further simplifi cation of arcyriafl avin A. Remarkably, this compound is inactive against PKC and is selective for the EGF-R kinase active site. Suggest why there might be such a drastic change in selectivity.
5 step solution
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