Chapter 14
An Introduction to Medicinal Chemistry · 2 exercises
Problem 3
Carbidopa (Fig. 14.34) protects levodopa from decarboxylation in the peripheral blood supply, but is too polar to cross the blood-brain barrier into the central nervous system. Carbidopa is reasonably similar in structure to levodopa, so why can it not mimic levodopa and cross the blood-brain barrier by means of a transport protein?
5 step solution
Problem 7
The oral bioavailability of the antiviral drug aciclovir is only \(15-30 \%\). Suggest why this may be the case and how one might increase the bioavailability of this drug. $$ \underset{\mathrm{Me}_{3} \mathrm{~N}\left(\mathrm{CH}_{2}\right)_{10} \mathrm{NMe}_{3}}{\stackrel{\oplus}{\odot}} $$ Decamethonium Miotine Aciclovir
3 step solution