Chapter 12
An Introduction to Medicinal Chemistry · 4 exercises
Problem 2
What are the advantages and disadvantages of natural products as lead compounds?
4 step solution
Problem 3
Fungi have been a richer source of antibacterial agents than bacteria. Suggest why this might be so.
6 step solution
Problem 4
Scuba divers and snorkellers are advised not to touch coral. Why do you think this might be? Why might it be of interest to medicinal chemists?
4 step solution
Problem 5
You are employed as a medicinal chemist and have been asked to initiate a research programme aimed at fi nding a drug which will prevent a novel tyrosine kinase receptor from functioning. There are no known lead compounds that have this property. What approaches can you make to establish a lead compound? (Consult section 4.8 to fi nd out more about protein kinase receptors.)
6 step solution