Chapter 18

Clinical Chemistry · 12 exercises

Problem 1

Extreme copper deficiency is seen in what fatal condition? a. Menkes' disease b. Klinefelter's syndrome c. Meese disease d. Kayser-Fleischer rings

4 step solution

Problem 2

Suppose the controller on a GFAAS is defective and the furnace is running cold. What effect will this likely have on the number of photons absorbed in the measurements? a. It will decrease the number of photons absorbed. b. It will increase the number of photons absorbed. c. It will have little effect. d. It is not a relevant question because AAS relies on emission of light from electronically excited atoms.

5 step solution

Problem 3

Why would a clinical chemist develop an arsenic method that combines liquid chromatography with ICP-MS? a. To separate and quantitate several different arsenic-containing species in the same sample b. To eliminate interference by sodium from the analysis c. To shorten the run time of the measurement d. To lower the coefficient of variation for total arsenic measurements

6 step solution

Problem 4

Select the answer that designates three techniques widely used for elemental analysis, identified according to the initials for the techniques. a. AAS, ICP-MS, AES b. NMR, ICP-MS, AES c. GC-MS, ICP-MS, AES d. HPLC-ICP-MS, AAS, FTIR

4 step solution

Problem 5

One of the calcium isotopes \(\left({ }^{40} \mathrm{Ca}\right)\) has an atomic weight of \(40 .\) At what positions in a mass spectrum would singly and doubly charged ions of this isotope of calcium appear? Assume that singly charged Ca is listed first. a. 40 and 20 b. 40 and 60 c. 40 and 80 d. 40 and 40

4 step solution

Problem 6

What primary purposes does the torch serve in ICP-MS? a. Vaporization, atomization, and ionization b. Vaporization, atomization, and electronic excitation c. Nebulization, atomization, and photon absorption d. Droplet transport, vaporization, and ion detection

4 step solution

Problem 7

Manganese toxicity resembles the following disease: a. Parkinson's disease b. Wilson's disease c. Alzheimer's disease d. Menkes' disease

4 step solution

Problem 8

Iron is physiologically active only in the ferrous form in a. Hemoglobin b. Cytochromes c. Ferritin d. Transferrin

5 step solution

Problem 9

A metal ion required for optimal enzyme activity is best termed a(an) a. Cofactor b. Accelerator c. Coenzyme d. Catalyst

4 step solution

Problem 10

Which trace metal is contained in glucose tolerance factor? a. Chromium b. Copper c. Selenium d. Zinc

3 step solution

Problem 11

What metal may be used as a treatment for Wilson's disease? a. Zinc b. Copper c. Molybdenum d. Fluorine

4 step solution

Problem 12

The metal ion essential for the activity of xanthine oxidase and xanthine dehydrogenase is a. Molybdenum b. Iron c. Zinc d. Manganese

3 step solution

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