Chapter 46

Which type of cancer is treated with trastuzumab if the cells overexpress human epidermal growth factor receptors? (A). breast cancer (B). ovarian cancer (C). non-Hodgkin lymphoma (D). multiple myeloma (E). melanoma

Which immunosuppressant drug forms a complex with the FK-binding protein, resulting in inhibition of calcineurin and \(T\) lymphocyte activation? (A). cyclosporine (B). prednisone (C). cyclophosphamide (D). tacrolimus (E). azathioprine

The monoclonal antibody, ipilimumab, is an example of which type of immunotherapeutic agent? (A). protein inhibitor (B). TNFa blocker (C). kinase inhibitor (D). nuclear pore blocker (E). immune checkpoint inhibitor

Nivolumab is a monoclonal antibody indicated for the treatment of renal cell carcinoma, non-small cell lung cancer, and small cell lung cancer. Which protein does nivolumab target? (A). programmed death (PD-1) protein (B). cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) (C). signaling lymphocytic activation molecule family member 7 (SLAMF7) (D). ganglioside type GD2 (GD2) protein (E). epidermal growth factor (EGF) receptor

What two types of drugs form the antibody-drug conjugate class of antineoplastic agents? (A). mRNA strand and monoclonal antibody (B). Cytotoxic antibody and immunosuppressant (C). Targeted antibody and cytotoxic agent (D). Two cytotoxic agents joined by an antibody linker (E). Targeted antibody and IL antagonist