Chapter 45
Brenner and Stevens’ Pharmacology · 5 exercises
Problem 1
A woman being treated for breast cancer develops numbness and tingling in her hands and feet. Which drug most likely caused this adverse effect? (A). cyclophosphamide (B). docetaxel (C). doxorubicin (D). tamoxifen (E). temsirolimus
5 step solution
Problem 2
Which adverse effect may result from cisplatin therapy? (A). cardiac toxicity (B). liver failure (C). muscle toxicity (D). nephrotoxicity (E). hemolytic anemia
4 step solution
Problem 3
A woman with chronic myeloid leukemia responds to imatinib therapy as indicated by a cytologic remission. Which enzyme is inhibited by this drug? (A). DNA polymerase (B). dihydrofolate reductase (C). BCR-ABL tyrosine kinase (D). thymidylate synthetase (E). hypoxanthine guanine phosphoribosyltransferase
4 step solution
Problem 4
Uridine triacetate is given as an antidote to counteract the toxic effects of which one of the following chemotherapeutic agents? (A). cyclophosphamide (B). doxorubicin (C). fluorouracil (D). tamoxifen (E). doxorubicin
4 step solution
Problem 5
Doxorubicin is used to treat breast cancer and other neoplasms. It works by: (A). DNA intercalation (B). inhibition of ribosomes (C). immune checkpoint inhibitor (D). DNA alkylation (E). targeted antibodies
3 step solution