Chapter 43

A man with HIV infection is taking darunavir, a protease inhibitor. Which adverse effect is associated with this class of drugs? (A) anemia (B) pancreatitis (C) neuropsychiatric reactions (D) peripheral neuropathy (E) elevated triglyceride and cholesterol levels

A patient with shingles receives a drug that is converted to penciclovir in the body. Which antiviral action is exerted by this agent? (A) blockade of guanosine triphosphate synthesis (B) inhibition of DNA polymerase (C) inhibition of viral entry (D) DNA chain termination (E) prevention of viral maturation

A woman with influenza is treated with zanamivir. Which step in viral replication is prevented by this drug? (A) entry into host cells (B) uncoating of viral nucleic acid (C) replication of viral nucleic acid (D) maturation of viral proteins (E) release of progeny virions

Which non-nucleoside drug is used to treat systemic acyclovir and ganciclovir- resistant herpesvirus infections, such as CMV esophagitis? (A) foscarnet (B) trifluridine (C) ribavirin (D) rilpivirine (E) efavirenz

Which drug inhibits nonstructural protein \(3-4 \mathrm{~A}\) and prevents maturation of hepatitis \(\mathrm{C}\) virus? (A) dasabuvir (B) ombitasvir (C) simeprevir (D) ledipasvir (E) daclatasvir