Chapter 27

Which of the following correctly describes monteleukast? (A) blocks receptors for leukotrienes \(\mathrm{C}_4, \mathrm{D}_4\), and \(\mathrm{E}_4\) (B) inhibits cytochrome P450 enzymes (C) is administered twice daily (D) inhibits formation of leukutriene \(\mathrm{A}_4\) (E) is excreted unchanged in the urine

Which drug used for the treatment of asthma inhibits 5-lipoxygenase? (A) theophylline (B) zileuton (C) zafirlukast (D) fluticasone (E) roflumilast

A woman with allergic conjunctivitis uses a drug that prevents the release of chemical mediators from mast cells. Which mechanism is responsible for this pharmacologic effect? (A) activation of beta \(a_2\)-adrenoceptors (B) decreased cytokine production (C) blockade of muscarinic receptors (D) inhibition of 5-lipoxygenase (E) blockade of calcium influx

A 15-year-old girl with severe asthma triggered by seasonal allergies is receiving twice-monthly injections of a monoclonal antibody. Which mediator of asthma is antagonized by this drug? (A) immunoglobulin E (B) leukotriene \(\mathrm{C} 4\) (C) major basic protein (D) histamine (E) interleukin-2

A man being treated for severe asthma experiences an episode of life- threatening tachycardia requiring emergency treatment. Which drug is most likely responsible for this adverse effect? (A) budesonide (B) ipratropium (C) formoterol (D) cromolyn (E) montelukast