Chapter 11

Which mechanism is responsible for the vasodilation effect of verapamil? (A) increased levels of cGMP (B) decreased binding of calcium to calmodulin (C) decreased formation of \(\mathrm{IP}_3\) (D) increased myosin light-chain kinase activity (E) increased metabolic efficiency

Which effect is caused by both atenolol and diltiazem? (A) decreased cAMP levels (B) increased cGMP levels (C) decreased heart rate (D) relaxation of arterial smooth muscle (E) inhibition of sodium influx

What is the mechanism by which isosorbide dinitrate increases cyclic GMP levels? (A) inhibition of phosphodiesterase (B) inactivation of aldehyde dehydrogenase (C) blockade of \(\beta\)-adrenoceptors (D) release of nitric oxide (E) blockade of calcium channels

A man with obstructive pulmonary disease requires therapy to prevent anginal attacks. Which drug should be avoided in this patient? (A) verapamil (B) felodipine (C) isosorbide mononitrate (D) diltiazem (E) propranolol

Which agent prevents myocardial cell calcium overload and thereby decreases ventricular wall tension? (A) ranolazine (B) nitroglycerin (C) amlodipine (D) ivabradine (E) trimetazidine