Q57 E - Organic Chemistry (Mcmurry)

Question

Outline methods for the preparation of acetophone(Phenyl methyl ketone) starting from the following:

 a)Benzene       b) Bromobenzene  c) Methyl benzoate

d)  Benzonitrile e) Styrene

Step-by-Step Solution

Answer

All the preparation of acetophenone (Phenyl methyl ketone) from Benzene, Bromobenzene, Methyl benzoate, Benzonitrile, and Styrene are shown here.

Preparation of acetophenone from Benzene

On using with in benzene, acetophenone is synthesized 

Preparation of acetophenone from Bromobenzene

On using with $Mg dry ether$ phenyl magnesium bromide is produced as a mid product followed by acetophenone is synthesized.

Preparation of acetophenone from Methyl benzoate

On using with $C{H}_{3 } Mg Br \text{dry} \text{ether}$ , will get acetophenone on the hydrolysis of mid product.

Preparation of acetophenone from Benzonitrile

On using with  and hydrolysis will get acetophenone.

Preparation of acetophenone from styrene

On using with $pd/Au/A{l}_2{O}_3 \text{in} H_2{O}_2 \text{or} C{O}_2 \text{medium}$  acetophenone is synthesized.

Conclusion

Therefore, all the preparation of acetophenone (Phenyl methyl ketone) from Benzene, Bromobenzene, Methyl benzoate, Benzonitrile, and Styrene are synthesized.