Q55E
Question
The aldol reaction is catalyzed by acid as well as the base. What is the reactive nucleophile in the acid-catalyzed aldol reaction? Propose a mechanism.
Step-by-Step Solution
Verified Answer
The reactive nucleophile in the acid-catalyzed aldol reaction is the enol and electrophile is a protonated carbonyl group.
1Formation of Enol:
2Addition of enol to the protonated carbonyl group:
3loss of +H ion from the carbonyl oxygen:
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