Q.40. - Organic Chemistry

Question

Question: What starting materials are needed to synthesize each compound by a crossed Claisen reaction?

Step-by-Step Solution

Answer

Answer

Step 1: Crossed-Claisen reaction

The Claisen reaction involves two different ester groups: one that can form an enolate and the other that cannot. The $\mathit{\alpha }$-hydrogen of one ester gets deprotonated and attacks at the electrophilic carbonyl carbon center of the other.

Step 2: Retrosynthetic analysis

Retrosynthesis is the method employed to determine the synthetic pathway of a reaction and the starting materials participating in the reaction.

 

The analysis is done based on the product, and the breakdown is performed by keeping it as the target molecule.

Step 3: Determination of the starting materials

a.

The retrosynthetic analysis of the given compound is as follows.

Retrosynthesis of compound a

 

b.

The retrosynthetic breakdown of the given compound is as follows.

Retrosynthesis of compound c

 

d.

The retrosynthetic breakdown of the given compound is as follows.

Retrosynthesis of compound d