Q37E
Question
21-37 Fats are biosynthesized from glycerol 3-phosphate and fatty-acyl CoA's by a reaction sequence that begins with the following step. Show the mechanism of the reaction.
Step-by-Step Solution
Verified Answer
The reaction's mechanism is depicted in the diagram below.
1Step 1: Introduction to the Concept
A nucleophilic substitution reaction occurs when an electron-rich nucleophile contacts a positively charged electrophile in order to replace a leaving group.
2Step 2: Solution Explanation
A nucleophilic attack of an OH in glycerol 3-phosphate on the carbonyl of fatty acyl CoA yields a tetrahedral intermediate, which is then eliminated by â€"SCOA, which is then abstracted by a proton to generate 1-acylglycerol 3-phosphate in the final step.
The mechanism of the reaction is represented in the diagram below.
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