Q29-21E - Organic Chemistry (Mcmurry)

Question

Human brain natriuretic peptide (BNP) is a small peptide of  $\mathbf{32}$ amino acids used in the treatment of congestive heart failure. How many nitrogen bases are present in the DNA that codes for BNP?

Step-by-Step Solution

Answer

The nitrogen bases that are present in the DNA that codes for Human brain natriuretic peptide is 96 nucleotides.

Introduction

BNP (Brain Natriuretic Peptide) is a hormone released by cardiomyocytes in the heart ventricles in response to stretching induced by increasing ventricular blood volume.

Nitrogen bases present in DNA codes for BNP

From the given data,

The BNP contains  amino acids.

The total number of nitrogen bases in the DNA that code BNP is,

$$\begin{gathered} =32\times 3 \\ =96 \end{gathered}$$

Codons are three-nucleotide groups utilized in translation to convert a DNA sequence to an amino acid sequence via mRNA. There must be three times as many nucleobases, or $\mathbf{96}$ nucleotides, as there are 32 amino acids.