Q.17.66 - An Introduction to General, Organic, and Biological Chemistry

Question

Consider the following segment of mRNA produced by the normal order of DNA nucleotides: 

CUU AAA CGA CAU

a.  What is the amino acid order produced from this mRNA?

b. What is the amino acid order if a point mutation changes from CUU to CCU?

c. What is the amino acid order if a point mutation changes from CGA to AGA?

d. What is the amino acid order of the insertion mutation adds a G to the beginning of the mRNA segment?

e. What is the amino acid order of the deletion mutation removes C to the beginning of the mRNA segment? 

Step-by-Step Solution

Answer

a. N-Leu-Lys-Arg-His-C

b. N-Pro-Lue-Lys-Arg-His-C 

c. N-Leu-Lys-Arg-Val-C 

d.  The new mRNA sequence is GCU UAA ACG ACA U

e. The new mRNA sequence is UUA AAC GAC AU

Step1 : Part (a) Given information

The order of DNA nucleotide is:

CUU AAA CGA CAU

Step 2: Part (a) Explanation

The table from the book is given which is as follows:

The order of DNA nucleotide is given as:

CUU AAA CGA CAU

Thus, using the values from the table the amino acid order produced from this mRNA is as follows:

N-Leu-Lys-Arg-His-C 

where N represents the 5' terminal and C represents the 3' terminal.

Step 1: Part (b) Explanation

The table from the book is given which is as follows:

The order of DNA nucleotide is given as:

CUU AAA CGA CAU

If a point mutation changes from CUU to CCU. Thus, using the values from the table the amino acid order produced from this mRNA is as follows:

N-Pro-Lue-Lys-Arg-His-C  

where N represents the 5' terminal and C represents the 3' terminal.

Step 1: Part (c) Explanation

The table from the book is given which is as follows:

The order of DNA nucleotide is given as:

CUU AAA CGA CAU

If a point mutation changes from CGA to AGA  Thus, using the values from the table the amino acid order produced from this mRNA is as follows:

N-Pro-Lue-Lys-Arg-His-C  

where N represents the 5' terminal and C represents the 3' terminal.

Step 1: Part (d) Explanation

The table from the book is given which is as follows:

The order of DNA nucleotide is given as:

CUU AAA CGA CAU

if the insertion mutation adds a G to the beginning of the mRNA segment, Then, the new mRNA sequence is GCU UAA ACG ACA U which signifies N-Ala-STOP.

Step 1: Part (d) Explanation

The table from the book is given which is as follows:

The order of DNA nucleotide is given as:

CUU AAA CGA CAU

If the deletion mutation removes C to the beginning of the mRNA segment. Then, the new mRNA sequence is UUA AAC GAC AU.