Q. 35 - Biology

Question

What cell-cycle events will be affected in a cell that produces mutated (non-functional) cohesin protein?

Step-by-Step Solution

Answer

If a mutation leads to the production of non functional cohesin molecules, the alignment of duplicated DNA disrupts and segregation of chromosomes will also restricted.

Step 1. Introduction

A cell cycle consist of series of events that takes place in a cell for growth and division.

Step 2. Concept

When the mutated cohesin proteins is produced, it directly affects the anaphase of cell-division cycle because  the chromosomes are not equally segregated and duplicated DNA would not aligned in proper manner.

Step 3. Explanation

The events of cell cycle are grouped into two categories:

(1.) Interphase stage (Preparatory phase)

(2.) Mitotic phase (Division stage)

Different protein molecules play an important role in cell-division cycle e.g. Cohesin protein involves in linking sister chromatids and align them  properly; also ensures the equal segregation of chromosomes during anaphase.

Now in case of mutated cohesin protein, the segregation of chromosomes will affected i.e. unequal. As a result, the daughter cells carries abnormal chromosomes content.