Q. 18.40 - An Introduction to General, Organic, and Biological Chemistry

Question

What is the total $\mathrm{NADH}$ and total ${\mathrm{FADH}}_2$ produced in one turn of the citric acid cycle?

Step-by-Step Solution

Answer

The three $\mathrm{NADH}$ and one ${\mathrm{FADH}}_2$ produced in one turn of the citric acid cycle

Step 1: Given information

We need to find the $\mathrm{NADH}$ and ${\mathrm{FADH}}_2$ produced in one turn of the citric acid cycle

Step 2: Explanation

We know that

Three ${\mathrm{NAD}}^{+}$ are reduced to three $\mathrm{NADH}$ in one rotation of the citric acid cycle via four oxidation processes. They also convert one $\mathrm{FAD}$ to one ${\mathrm{FADH}}_2$. For one rotation of the citric acid cycle, the overall chemical equation is:

$$\begin{gathered} \mathrm{Acetyl}-\mathrm{CoA}+3{\mathrm{NAD}}^{+}+\mathrm{FAD}+\mathrm{GDP}+{\mathrm{P}}_{\mathrm{i}}+2{\mathrm{H}}_2\mathrm{O}\to \\ 2{\mathrm{CO}}_2+3\mathrm{NADH}+3{\mathrm{H}}^{+}+{\mathrm{FADH}}_2+\mathrm{HS}-\mathrm{CoA}+\mathrm{GTP} \end{gathered}$$