Q. 17.9 - An Introduction to General, Organic, and Biological Chemistry

Question

Suppose parent chain, adenine, is replaced by guanine. (17.3, 17.4, 17.5, 17.6)

 a. What type of mutation has occurred?

b. Using the new strand that results from this mutation, write the order of bases in the altered mRNA.

c.Write the three letter symbol for the amino acids that would go into peptide from the mRNA you wrote in the part b.

d.What effect,if any,might this mutation have on the structure and/or function of the resulting protein.

Step-by-Step Solution

Answer

The answer to these question is:

a) Mutation occured is point mutation.

b) The completed changed strand is shown below: CCCAGCGGA.

c) GGGUGCGCCU are the three-letter symbols.

d) The substrate won't attach to the active site.

Part (a) Step 1: Given information

We have to tell about the mutation occuring.

Part (a) Step 2: Explanation

Adenine (A) partners with thymine (T), and cytosine (C) couples with guanine (G) in DNA (G).

If the first nucleotide in the parent chain, adenine, is replaced by guanine, a point mutation occurs in the DNA section below: AGGTCGCCT AGGTCGCCT GGGTCGCCT GGGTCGCCT

Part (b) Step 1: Given information

We have to tell order of bases .

Part (b) Step 2: Explanation

Except for A in DNA, which is linked with U in RNA, the nucleotides in mRNA are complementary to those in DNA.

The completed changed strand is shown below: CCCAGCGGA N

GGGUGCGCCU will be the changed mRNA sequence.

Part (c) Step 1: Given information

We have to tell three letter symbol for the amino acids.

Part (c) Step 2: Explanation

GGGUGCGCCU are the three-letter symbols for the amino acids that would make up the peptide from the mRNA below.

Part (d) Step 1: Given information

We have to tell  function of the resulting protein. 

Part (d) Step 2: Explanation

Because of the altered amino acid sequence, the produced protein has a different structure and function. If the protein is an enzyme, it may lose biological activity if it can't catalyse a process because the substrate won't attach to the active site.